While Wine is usually thought of as a Windows(TM) emulator, the Wine
developers would prefer that users thought of Wine as a Windows
compatibility layer for UNIX. This package includes a program loader,
which allows unmodified Windows 3.x/9x/NT binaries to run on x86 and x86_64
Unixes. Wine does not require MS Windows, but it can use native system
.dll files if they are available.
In Fedora Extras wine is actually a meta-package which will install everything
you need for wine to work smoothly. If you don't want to install everything
take a look at the wine-* packages.